Which clinical sign is NOT associated with renal disease?

Jaundice is primarily associated with liver dysfunction and disease rather than renal disease. It occurs when there is an accumulation of bilirubin in the bloodstream due to issues with liver processing or bile flow. In contrast, renal disease typically presents with symptoms related to the kidneys' ability to filter waste and manage fluid balance.

Oliguria, a reduced urine output, is a common sign of renal impairment, indicating a problem with kidney function. A palpable flank mass can signify conditions such as hydronephrosis or renal tumors, both of which are directly linked to renal pathology. Generalized edema is also related to kidney issues, as it reflects fluid retention due to the kidneys' inability to excrete sodium and water properly.

Thus, while oliguria, a palpable flank mass, and generalized edema are all clinical signs that indicate renal dysfunction, jaundice does not directly correlate with renal disease, making it the correct answer in this context.