What genetic disorder results in progressive stretching of all arterial vessels, leading to abnormal dilation?

Marfan's Syndrome is a genetic disorder that significantly affects connective tissue, which is essential for the structural integrity of various body systems, including the cardiovascular system. In individuals with Marfan's Syndrome, mutations in the FBN1 gene lead to abnormalities in fibrillin-1, a protein that plays a crucial role in the formation and maintenance of elastic fibers in connective tissue. As a result, the arterial walls become weakened and more prone to progressive stretching and dilation, which can cause conditions like aortic aneurysms and aortic dissection.

This progressive dilation is a hallmark of the condition, making it critical for those diagnosed with Marfan's Syndrome to undergo regular cardiovascular monitoring to manage and mitigate the risks associated with these vascular changes. Understanding this relationship between the genetic mutation and the vascular manifestations aids in both diagnosis and prevention strategies for individuals with Marfan's.